PNAS Plus Significance Statements Differential sensing for the regio- and stereoselective identification and quantitation of glycerides
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چکیده
Lipid metabolism is a growing area of biochemical research because understanding these pathways could lead to treatments for metabolic disorders such as obesity and type 2 diabetes. To study lipid metabolism, researchers need tools to identify and quantitate glycerides, the main component of animal fat. However, it can be difficult to tell one glyceride apart from another subtly different glyceride using current analytical methods such as mass spectrometry. Thus, we developed a method of discriminating glycerides using an array of cross-reactive proteins in conjunction with pattern recognition algorithms. By incorporating an olefin metathesis pretreatment step, we were able to distinguish glyceride regioand stereoisomers and to predict these structural features. Finally, we achieved quantitation of glycerides in mixtures. (See pp. E3977–E3986.)
منابع مشابه
Differential sensing for the regio- and stereoselective identification and quantitation of glycerides.
Glycerides are of interest to the areas of food science and medicine because they are the main component of fat. From a chemical sensing perspective, glycerides are challenging analytes because they are structurally similar to one another and lack diversity in terms of functional groups. Furthermore, because animal and plant fat consists of a number of stereo- and regioisomeric acylglycerols, t...
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تاریخ انتشار 2015